PRMT1 and cancer: Though there are many reports available in the literature to show that DNMTs/HMTs are overexpressed in a wide variety of cancers, we provide strong evidence that the down-regulation of methyltransferases such as DNMT3A, PRMT1, SUV39H1, and HDAC2 is linked to the hyperacetylation of H2A, H2B, H3, and H4 following SAHA treatment.