Furthermore, another methyltransferase, suppressor of variegation 3–9 homolog 1 (SUV39H1), is the su(var)3–9, enhancer-of-zeste, trithorax (SET)-domain-containing histone lysine methyltransferase that catalyzes the trimethylation of H3K9 (histone3 lys9), which is also known to play a significant role during cancer development. The gene discussed is SUV39H1; the disease is cancer.