It was shown that SBE imposed a negative effect by increasing the IFNγ production in PBLs and reduced the IL-10 and TNFα production in bone marrow cells (BMC) of ALL patients, and controlled the production of cytokines, which stimulate nonspecific resistance in ALL patients and have an essential role in the innate immune system [155]. The gene discussed is IFNG; the disease is acute lymphoblastic leukemia.