RNA-binding proteins, such as TAR DNA-binding protein 43 (TDP-43) and fused-in-sarcoma (FUS) associated with FTD and ALS, were found to be the largest group of proteins susceptible to aggregation during ischemia, suggesting ischemia as a trigger condition for protein misfolding and aggregation in neurodegenerative disorders [15]. Here, TARDBP is linked to amyotrophic lateral sclerosis.