A study on the PD model revealed that lncMALAT1 promoted DA neuron apoptosis through the NF-κβ signaling pathway by sponging with miR-124 [50], thereby suggesting that the lncMALAT1-miR-124-MEKK3/NF-κβ axis may provide new insight for the treatment of the neuroinflammation caused by the activation of microglia (Figure 6B). The gene discussed is MAP3K3; the disease is Parkinson disease.