NLRP3 and Parkinson disease: Further studies have shown that miR-223-3p is a negative regulator of NLRP3 protein (a key protein of inflammasome) involved in regulating pathological processes in various disorders, including cancer, autoimmune and inflammatory diseases, etc. Roberta Mancuso et al., in 2019, reported that the serum concentration of miR-223-3p could be a differential diagnosis and serve as a potential non-invasive biomarker for AD, PD, and mild cognitive impairment (MCI) [210].