The hypoadropinemia was linked to the NAFLD pathogenesis through Adropin-related endothelial dysfunction, depending on the ability of Adropin to induce the expression of nitric oxide (NO) into the endothelium, i.e., hypoadropinemia will be associated with a reduction of the NO in endothelial cells [42]. This evidence concerns the gene ENHO and metabolic dysfunction-associated steatotic liver disease.