In this sense, it has been shown that MNKI-8e, an inhibitor of Mnk, as well as Mnk knockdown generated by short hairpin RNA (shRNA), improves the ability of Ara-C to induce apoptosis in MV4-11 AML cells by suppressing the expression of antiapoptotic proteins such as Mcl-1. Here, ATP7A is linked to acute myeloid leukemia.