Hydroxyurea (HU), an RNR inhibitor used clinically to control myeloproliferative disorders, sickle cell anemia and acquired immunodeficiency syndrome (AIDS), as well as azidothymidine (AZT), a nucleotide thymidine analog drug for treating human immunodeficiency virus (HIV) infection both have the ability to reverse cell resistance to cisplatin in resistant cell lines due to the synergistic activity between HU and AZT based upon their shared deleterious impact on the depletion of cellular dTTP [102]. Here, NR2E3 is linked to AIDS.