SAMHD1 and acute myeloid leukemia: Likewise, other mechanisms of drug resistance based on the regulation of individual genes in AML relapse have been proposed; these genes include SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1), EZH2 (enhancer of zeste homolog 2) and KDM6A (lysine demethylase 6A).