Nobiletin suppressed IL-1β-induced proinflammatory mediators, including prostaglandin E2, nitric oxide, cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor-a, and IL-6 by inhibiting Akt and NF-κB activation in human osteoarthritis chondrocytes [29]. Here, NOS2 is linked to osteoarthritis.