Nobiletin suppressed IL-1β-induced proinflammatory mediators, including prostaglandin E2, nitric oxide, cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor-a, and IL-6 by inhibiting Akt and NF-κB activation in human osteoarthritis chondrocytes [29]. The gene discussed is IL1B; the disease is osteoarthritis.