This imbalance in mitochondrial dynamics is in agreement with a study that reported alterations in fission/fusion in BD, where it was observed downregulation of the mitochondrial fusion-related proteins Mfn-2 and Opa-1 and the upregulation of the fission protein Fis-1 in PBMCs from patients with BD [22]. The gene discussed is OPA1; the disease is Behcet disease.