Activation of nuclear β1 and/or nuclear β3 adrenoceptors seems to cause a reduction of nuclear factor kappa-light-chain-enhancer of activated B-cell (NF-κB), an activation of transcription factor 2 (ATF-2), of the interleukin-1 type 1 (IL1r1) receptor and an increase of tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b) transcription in inflammation related with congestive heart failure and atrial fibrillation [88]. The gene discussed is TNFRSF1B; the disease is atrial fibrillation.