After inducing ischemia in the rodent brain, NRP1 translocates from non-raft domains to lipid rafts, together with Fer kinase, which regulates axon extension inhibition, and collapsing response mediator proteins (CRMPs) [114], known to mediate NRP1 response to Sema3A during axonal retraction of DRG neurons [115]. This evidence concerns the gene NRP1 and ischemia.