Combining NPG with HO-1 inhibitor demonstrated down-regulation of genes involved in cancer cell invasion and proliferation (EGR1, CXCL2, AREG, CXCL3, EREG, CD3e, CD3g, CD74, and B2M) as compared to NPG or to control animals (Figure 8C). The gene discussed is HMOX1; the disease is cancer.