Combining NPG with HO-1 inhibitor demonstrated down-regulation of genes involved in cancer cell invasion and proliferation (EGR1, CXCL2, AREG, CXCL3, EREG, CD3e, CD3g, CD74, and B2M) as compared to NPG or to control animals (Figure 8C). This evidence concerns the gene CXCL3 and cancer.