To evaluate the effects of HO-1 inhibition on chemotherapy-resistant pancreatic tumor cell lines, we treated GEM-resistant (GR) cell lines MiaPaCa-2 and T3M4 and their parental cells with GEM or with NPG in the presence of the HO-1 inhibitors ZnPP and SnPP. The gene discussed is HMOX1; the disease is pancreatic neoplasm.