Furthermore, cyclooxygenase-2 (COX-2), cytosolic phospholipase, interleukin-1β (IL-1β), and the β-amyloid precursor protein of proinflammatory and neurodegenerative gene were found to be upregulated in the American Tissue Culture Collection of glioma and glioblastoma. The gene discussed is PTGS2; the disease is glioma.