However, when the Tie2-Cre; Lrp2flx/flx animals EMD mice in [33,42] were challenged with a high-fat diet, they did not develop obesity as wild-type animals did [42], arguing against a role of LRP2 as leptin transporter in the BBB. The gene discussed is LRP2; the disease is obesity due to melanocortin 4 receptor deficiency.