Nonetheless, in light of recent results using the Tie2-Cre; Lrp2flx/flx mice, our preliminary data using Slco1c1-CreERT2; Lrp2flx/flx mice indicate that LRP2 at the BBB is not specifically involved in the development of obesity. This evidence concerns the gene LRP2 and obesity due to melanocortin 4 receptor deficiency.