IL22 and bacterial infectious disease: Specifically, the downregulated genes are related to neutrophil cell migration (mpx, sgk1) [50], leukocyte recruitment (Irg1l) [51], macrophage chemotaxis to the site of bacterial infection (Cxcr3.2) [52], mucus production (cftr) [53], wound healing, and protection against microbes (il22) [54].