Moreover, induced expression of miR-21 high-mobility group box 1 (HMGB1) causes downregulation of its targets, TIMP metallopeptidase inhibitor 3 (TIMP3) and RECK that, in turn, increase the levels of matrix metallopeptidase (MMP) proteins, thereby mediating HCC progression and metastases [50]. This evidence concerns the gene RECK and hepatocellular carcinoma.