Similarly, downregulation of miR-21 consequently inhibits the proliferation, invasion, and migration of esophageal squamous cell carcinoma (ESCC) cells by negatively regulating the expression of PDCD4 [51] or PTEN [45] via the PTEN/PI3K/AKT signaling pathway [46]. The gene discussed is PTEN; the disease is esophageal squamous cell carcinoma.