The plasmin–α-2-antiplasmin complex was significantly increased (FC = 2.4; punadj = 4.60−5; Figure S4a) in the plasma of patients with lung cancer, and the significant correlation with the 55 kDa fragment of F13A1 in platelets (rs = 0.451; punadj = 4.44−3; Figure 4a) supports the theory of plasmin-mediated degradation of F13A1. Here, PLG is linked to lung cancer.