In line with the assumption that the processing and release of this glycoprotein may be influenced by the enhanced pathway of “protein processing in ER”, a significant positive correlation was detected between the ER-chaperoning proteins’ CALR spot abundances (spot 3: rS = 0.557; punadj = 3.41−4) and HSPA5 (spot 15: rS = 0.628; punadj = 3.23−5) of platelets with the corresponding plasma values of FVIII from patients with lung cancer and matched controls (Figure 5a,b). Here, HSPA5 is linked to lung carcinoma.