In the study by Bauerova and co-workers, methotrexate combined with pinosylvin had a superior effect in adjuvant arthritis in the rat as compared to the treatment with methotrexate alone in decreasing the activity of lipoxygenase, in reducing circulating levels of thiobarbituric acid reactive substances, and in increasing the expression of heme oxygenase-1 in the lungs [20]. Here, HMOX1 is linked to arthritic joint disease.