IL7R and acute lymphoblastic leukemia: Recently, Akkapeddi et al., and Hixon and colleagues developed human and chimeric mouse–human monoclonal antibodies targeting IL-7Rα, which induced antibody-dependent cell-mediated cytotoxicity against T-ALL cells in vitro and were effective for treating T-ALL in PDX models of both established and relapsed disease in vivo [143,144].