Moreover, the intravenous injection of IL-7Rα p.L242-L243insNPC-expressing D1 cells, as well as IL-7Rα p.L242-L243insGC- and IL-7Rα p.IL241–242TC-positive Arf-/- thymocytes into Rag-/- mice resulted in leukemia development. Here, IL7R is linked to leukemia.