Yao et al. used a self-assembled DNA-nanocross functionalized by four AS1411 aptamers for doxorubicin delivery to target the overexpressed nucleolin localized on the colorectal tumor cell surface and found that the drug-delivery system developed was selectivity delivered to colorectal carcinoma cells and presented an enhanced antitumor efficacy compared to free doxorubicin [127]. Here, NUCLEOLIN is linked to colorectal carcinoma.