Therefore, 83 cases had HCC-R after DAA treatment; however, these cases did not show the worsening of tumor-specific factors (such as number, size, and BCLC staging classification), of tumor markers (such as AFP and DCP) or of liver functional indexes (such as AST, ALT, and bilirubin), and of Child–Pugh score. Here, ACE is linked to hepatocellular carcinoma.