In B-cell ALL, genetic alterations, which are specific to each ALL immunophenotype, include hyperdiploidy, hypodiploidy, BCR-ABL1, ETV6-RUNX1 or TCF3-PBX1 fusions, PAX5 or ETV6 mutations, MLL rearrangements, or intrachromosomal amplification of chromosome 21 (iAMP21) specific for B-ALL. This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.