We performed research on PubMed/Medline, Cochrane library, and Scopus using the keywords “cholangiocarcinoma”, “intrahepatic cholangiocarcinoma”, “extrahepatic cholangiocarcinoma”, “biliary tract cancer”, “FGFR”, “FGFR2”, “pemigatinib”, “derazantinib”, “infigratinib”, “erdafitinib”, and “futibatinib”. The gene discussed is FGFR2; the disease is biliary tract neoplasm.