FGF2 and neoplasm: Accordingly, the pattern recognition receptor Long Pentraxin 3 (PTX3), a secreted/stromal component of innate immunity able to bind and inactivate various members of the FGF family, including FGF2, has revealed potent anti-angiogenic and anti-tumor properties in different FGF-dependent tumors [12,13,14,15,16,17].