FGF2 and Miyoshi myopathy: In keeping with the capacity of MM cells to stimulate ECs by direct interactions and production of pro-angiogenic factors, including FGF2 [2], human umbilical vein ECs (HUVECs) co-cultured with MM cells showed an increased rate of survival and proliferation as well as elevated levels of FGFR1 phosphorylation, when compared to HUVEC monocultures (Figure 1B,C).