PTX3 and neoplasm: Interestingly, when PTX3 expression is forced in neoplastic plasma cells, thus leading to an increase of the PTX3/FGF2 ratio, the activation of FGF/FGFR pathway is inhibited and EC activation is reduced both in in vitro co-cultures and in in vivo tumor graft models (i.e., chick embryo CAM, zebrafish and murine xenografts).