STING1 and vascular disorder: STING-associated vasculopathy with onset in infancy (SAVI) belongs to the first category of ailments and is caused by a gain-of-function mutation in the STING gene; this gene encodes a protein that is at the cross-roads between the cGAS (cyclic GMP-AMP synthase, an exogenous DNA sensor) and the interferon regulatory factors (IRFs)-3 and -7, which induce type I IFN transcription [20].