Finally, it is interesting to note that experiments in the experimental autoimmune encephalomyelitis (EAE) mouse model support the therapeutic potential of IL-1 blockade in MS [57], an approach that has been tested in a very limited number of patients suffering colchicine-resistant familial mediterranean fever (FMF, an inflammasomopathy) and MS [58]. The gene discussed is IL1B; the disease is myeloid sarcoma.