CCN2 and methicillin-resistant staphylococcus aureus infectious disease: Although vitamin E has been widely used since many years in the dermatologic and skin care industry because of its well-known antioxidant effect, recent studies suggest that it plays an important role in gene expression and cell signaling, leading to an increased immune defense against methicillin-resistant Staphylococcus aureus (MRSA) infections, modulating the connective tissue growth factor (CTGF) expression and regulating the cell structure and stability [110,111].