They demonstrated that in vivo sakuranetin treatment with a dose of 20 mg/kg/BALB/c in mice reduced serum IgE levels, lung inflammation (eosinophils, neutrophils, and Th2/Th17 cytokines), and respiratory epithelial mucus production in ovalbumin-sensitized (for 30 days) animals in a murine experimental asthma model. The gene discussed is IGHE; the disease is asthma.