The loss-of-function mutations in STAT3, found in autosomal dominant-hyper IgE syndrome (AD-HIES) correlates with lower rates of anaphylaxis, which may be explained by reducing mast cell degranulation [77], and affecting the architecture and functional dynamics of endothelial junctions, thus preventing vascular permeability [76]. The gene discussed is STAT3; the disease is anaphylaxis.