The third is that in our previous report, RT-R-MDA-MB-231 cells also showed an increased STAT 3 activity, which was reported to be related to cancer stemness and EMT, but that the inhibition of STAT 3 activity by the JNK inhibitor or Janus-activated kinase 2 (JAK2) inhibitor could not suppress the increased expression of CSC markers [50]. This evidence concerns the gene MAPK8 and cancer.