Enrollment of 10 new patients affected by HNSCC and surgically treated allowed an in-depth phenotypic characterization showing that both CD8+CD28−PD-1hi T cells and CD8+CD28−CD127−CD39+PD1hi Treg may express the CD103 integrin, characterizing stably resident cells within the tumor (Figure 5A), as well as the CD137 antigen, a marker of recently TCR-stimulated T lymphocytes with potential anti-tumor reactivity (Figure 5B) [34,35,36,37]. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.