We noted that tumor infiltrating CD8+CD28− T cells of HNSCC patients could be divided in three subgroups (CD8+CD28−PD-1hi, CD8+CD28−PD-1int and CD8+CD28−PD-1lo/absent T cells) based on their PD-1 mean fluorescence intensity (MFI), reminiscent of what was recently observed in CD8+ T cells from the infiltrate of lung cancer (Figure 2A,C, Figure 2B left panels) [27]. Here, CD8A is linked to neoplasm.