Figure 5C shows that 0.8% of total tumor infiltrating CD8+ T cells, 0.28% of CD8+CD28−PD-1hi T cells and 0.5% of CD8+CD28−CD127−CD39+PD-1hi Treg bound specifically to the HLA-A2 G250/CAIX loaded pentamer, demonstrating that they contained tumor-reactive CD8+ T cells. This evidence concerns the gene CA9 and neoplasm.