Investigation into the relationship between the inflammasome and heterochromatic silencing of EBV also provides mechanistic insights into medical observations related to three human herpesviruses: (1) Diabetes, which frequently activates the NLRP3 inflammasome [62,63], was found to substantially increase the risk of development of EBV-lymphomas in renal transplant recipients in a large Australian study [64]. This evidence concerns the gene NLRP3 and lymphoma.