Interestingly, although the association of cTn with LV hypertrophy and underlying HF has been established, the definition of universal cut-offs among asymptomatic individuals might be challenging due to the influence of age, gender, body mass index, and systolic pressure on cTnI levels and the effect of diabetes mellitus on cTnT [19,20,22]. The gene discussed is TNNI3; the disease is diabetes mellitus.