CASP3 and myocardial infarction: It was shown in rats with induced myocardial infarction by occluding the left anterior coronary artery, administration of probiotics based on combination of Lactobacillus helveticus and Bifidobacterium longum reduces Bax/Bcl-2 (pro-apoptotic/anti-apoptotic) ratio and caspase-3 (pro-apoptotic) activity in the amygdala and dentate gyrus in comparison with the placebo group decreasing the predisposition of apoptosis in different cerebral regions associated with myocardial infarction [152].