Unlike other popular neuroblastoma cell models (e.g., Kelly and BE2C [14]), SY5Y is characterized by a normal copy number of the oncogene MYCN, a F1174L mutation in the ALK gene, and by a number of genomic aberrations such as deletions in the q23 band of chromosome 11 and by amplifications of the q21 band of chromosome 17 [15]. The gene discussed is MYCN; the disease is neuroblastoma.