Additionally, mango peel extracts reduced cell viability via γH2AX-mediated apoptosis associated with ROS induction, the activation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated protein kinase 1 and 2 (ERK1/2), manganese superoxide dismutase (MnSOD), and nuclear factor erythroid 2-related factor 2 (Nrf2) in human colorectal cancer cell lines (Caco-2, HCT116, and HT-29) [101]. Here, NFE2L2 is linked to colorectal cancer.