The expression of TOPK is significantly higher in various cancers compared with in normal tissues according to The Cancer Genome Atlas database (http://gepia.cancer-pku.cn/) (accessed on 25 March 2021), as shown in Figure 1, with exceptions for head and neck squamous cell carcinoma (HNSC), kidney chromophobe carcinoma (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal clear cell carcinoma (KIRP), pheochromocytoma and paraganglioma (PCPG), prostate adenocarcinoma (PRAD), and thyroid carcinoma (THCA). The gene discussed is PBK; the disease is cancer.