PBK and malignant glioma: Moreover, application of fluorescently labeled TOPK inhibitor is used for cancer-specific imaging in a variety of tumors and can potentially improve patient care [34]; for example, the labeling of a TOPK inhibitor with F-18 has been exploited for positron emission tomography imaging in glioblastoma [35], and TOPK may represent a biomarker for malignant glioma [36].