Bac I and II are proven modulators of aquaporin 1 (AQP1), a transmembrane protein with water and ion channel functions, and, as monotherapies, bac I and II have been shown to exhibit a significantly less antimigratory effect on AQP1 non-expressing colon cancer cell line SW480 compared to moderately AQP1-expressing HT-29 [14]. Here, AQP1 is linked to colonic neoplasm.