A study by Cha et al. used CD68 and CD163 (described as an M2 macrophage marker in this study) to detect CLS-B in three groups of patients with breast adipose tissue (Group 1 from reduction mammoplasty; Group 2 from non-neoplastic tissue from resected breast cancer specimens; Group 3 from breast cancer tissue specimens) [86]. This evidence concerns the gene CD163 and breast cancer.