One of the components of this system is the ACE2 receptor, which is not only expressed in organs but, also, in blood vessels [48,50]; some studies have demonstrated the solubility of ACE2 in plasma, showing a significant increase in patients with heart failure and a correlation with the degree of severity of the disease [51], giving better results as a biomarker in the diagnosis and prognosis of patients with Chagas disease by independent or combined detection with BNP or ANP. This evidence concerns the gene NPPB and Chagas disease.