CD8A and cancer: T-cell evasive mechanisms that occur in the latter types of cancers include limited influx and migration (i.e., lack or down-regulated expression of chemo-attractants and/or adhesion molecules), antigen recognition (i.e., lack or down-regulated expression of molecules involved in antigen processing and/or presentation), and/or function of CD8 T-cells (i.e., presence of immune-suppressor cells, altered expression of immune or metabolic checkpoints, and/or activation of oncogenic pathways) [3,4].