VSIR and neoplasm: We observed that preferential localization of CD8+ T-cells in the tumor but not stromal compartment (i.e., high ratio between tumoral and stromal CD8 T-cell densities) significantly correlated with preferential localization of VISTA+ and CD11b+ cells in the same compartment (i.e., high ratio between tumoral and stromal VISTA+, CD11b+ cell densities) (Figure 6A).