In fact, the VISTA-associated T-cell exclusion score, in which we combined localization of VISTA+ and CD11b+ cells in tumor over stroma multiplied by localization of CD8+ T-cells in stroma over tumor, was significantly associated with short OS and outperformed the individual associations of either tumoral density of VISTA+, CD11b+ cells, or stromal density of CD8+ T-cells with short OS in MM. The gene discussed is ITGAM; the disease is Miyoshi myopathy.