The combination of abundance of VISTA+ and CD11b+ cells in the tumor but not stromal tissue together with low presence of CD8+ T-cells in the same tissue compartment, termed a high VISTA-associated T-cell exclusion score, was significantly associated with short OS [HR: 16.6; 95% CI: 4.54–62.50; p < 0.0001]. The gene discussed is VSIR; the disease is neoplasm.