DDIT3 and Insulin resistance: However, ubiquitous CHOP ablation only temporarily rescued the glucose intolerance of high-fat-fed Sepn1 KO mice, suggesting that ER stress and the consequent maladaptive CHOP-mediated response is involved in the insulin resistance phenotype of Sepn1 KO mice but also that the transient beneficial effect from constitutive CHOP ablation might be due to the fact that it leads to increased adiposity [52].