RECK+ was associated with (i) delayed tumor establishment, (ii) reduced tumor growth and volume, (iii) reduced endothelial and tumor cell populations, (iv) increased proportion of specific inflammatory cells, (v) higher collagen content and (vi) increased levels of several protease inhibitors, including TIMP2 and SerpinE1/PAI-1. This evidence concerns the gene SERPINE1 and neoplasm.