REN and endothelial dysfunction: Cerebrovascular disease in SARS-CoV-2 infection, according to Al-Ramadan et al., might be due to SARS-CoV-2 dysregulation of the renin–angiotensin system (RAS) by acting on ACE2 receptors, direct infection of the endothelial cell which can results in endothelial dysfunction and impaired cerebral vasoreactivity.