Cerebrovascular disease in SARS-CoV-2 infection, according to Al-Ramadan et al., might be due to SARS-CoV-2 dysregulation of the renin–angiotensin system (RAS) by acting on ACE2 receptors, direct infection of the endothelial cell which can results in endothelial dysfunction and impaired cerebral vasoreactivity. The gene discussed is REN; the disease is cerebrovascular disorder.