Several characteristics of nonkeratinizing EBV-positive NPC exist, including high expression of PD-L1 [118], dense lymphocytic infiltration [119] and prevalence of specific genetic alterations (CCDN1, PI3K/Akt, NF-kB, and epigenetic deregulations), providing potentially novel targets for immunotherapeutic and personalized medicine approaches [117]. This evidence concerns the gene AKT1 and nasopharyngeal carcinoma.