Due to the contradictory results within the literature regarding the tumor suppressor or oncogenic function of miR-125b in colon/colorectal malignancies we decided to profundity the mechanisms and associated phenotypes related to TP53 mutational status (a gene with high mutation frequency in colon cancer) and miRNA mediated modulation, as this gene was identified with strong evidence as a direct target of miR-125b (according to the data retrieved from mirTargetLink database: https://ccb-web.cs.uni-saarland.de/mirtargetlink/ accessed on 15 October 2020, data not presented). The gene discussed is TP53; the disease is malignant colon neoplasm.