Considering the opposing roles of TP53 in colon cancer based on the mutational status, tumor suppressor in the case of wild-type forms and oncogenic for some mutant forms, and also the significant percent of patients with TP53 mutation, we employed two different cellular models of colon cancer to investigate the therapeutic role of miR-125b: wild-type and mutant TP53 colon cancer cells. The gene discussed is TP53; the disease is malignant colon neoplasm.