In fact, the reduced expression of α2 and α5 laminin isoforms may be correlated with the morphological finding of reticulin framework disruption in carcinomas [38], while overexpression of laminin α3 might be related to the higher expression levels of this isoform observed in the dense intratumoral vascular network of ACC. The gene discussed is LAMA3; the disease is adrenal cortex carcinoma.