Moreover, osteopontin has been demonstrated to be over-expressed in many human tumors, including carcinomas of the breast [41], lung [42], ovary [43], stomach [44], liver [45], and prostate [46] as well as mesothelioma [47], and it was proposed as a potential prognostic marker in many of these neoplasms. Here, SPP1 is linked to mesothelioma.