In addition to an increase in GH concentration and a decrease in IGF-I concentration in the course of sepsis, a decrease in the concentration of insulin-like growth factor-binding protein 3 (IGFBP-3) and the increase in IGFBP-1, IGFBP-2, IGFBP-4 are also described [82,87,88]. This evidence concerns the gene GH1 and Sepsis.