To control for the possibility of the mother’s MCs influencing the antibody responses, we also included a group of KitW-sh/W-sh Ifnar1−/− Ifngr1−/− mice that were first reconstituted with IFN-sufficient bone marrow-derived mast cells (BMMCs) from WT mice (KitW-sh/W-sh(R) Ifnar1−/− Ifngr1−/−) prior to infection with DENV1 (as diagramed in Figure 3A). Here, IFNAR1 is linked to infection.