To study the maternal antibody-mediated response in progeny in the absence of MCs, KitW-sh/W-sh Ifnar1−/− Ifngr1−/− adult female mice were first infected with DENV1, as shown in Figure 3A, and 2 weeks post-infection, after the virus has been cleared, were paired with DENV-naïve male counterparts. Here, IFNGR1 is linked to infection.