TF and neoplasm: For PDAC, TF was shown to be a powerful determinant of primary tumor growth and metastatic potential in that genetic elimination of TF by gene editing in C57Bl/6-derived mouse PDAC ‘KPC’ cells (i.e., KrasG12D; p53R172H) resulted in significantly diminished tumor growth and experimental metastasis when cells transplanted back into C57Bl/6 immune competent mice [49].