STAT3 and Cowden disease: Among food components, the green tea polyphenol, epigallocatechin gallate (EGCG), further to its antioxidant properties, is able to influence many functions involved in CD pathogenesis, such as methylation, transduction, transcription factors, mitochondrial function, and autophagy, and limits the activation of the signal transducer and activator of transcription 3 (STAT3) pathway involved in CD development [124].