PPARG and cancer: Indeed, mutations or variants in fatty acid desaturase genes (FADS1, FADS2), the peroxisome proliferator-activated receptor genes (PPARA, PPARG), the X-ray repair cross-complementing protein 1 gene (XRCC1), and stearoyl-CoA desaturase gene (SCD1) influence the serum levels of LC-PUFA-omega-3 and omega-6 fatty acids, affecting metabolic pathways, inflammation, and cancer risk [138].