Unabated angiotensin II activity may also be in part responsible for endothelial dysfunction and COVID-19-associated organ injury through promoting microvascular thrombosis, coagulopathy, inflammation, hypofibrinolysis, interleukin-6 (IL-6) production, and ROS production [50,51,52,53,54,55,56,57,58]. This evidence concerns the gene IL6 and endothelial dysfunction.